Order 10 mg/mL Methadose oral concentrate online


10 mg/mL Methadose oral concentrate
from $100.49 for 1000 milliliters
QuantityPer unitPrice
1000 milliliters$0.10$100.49

Description of Methadone Oral Concentrate
Methadone Hydrochloride Oral Concentrate USP (methadone hydrochloride oral concentrate) is a raspberry-flavored liquid concentrate for oral administration that contains 10 mg of methadone hydrochloride per mL and contains methadone, an opioid agonist. Order 10 mg/mL Methadose oral concentrate online.

3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride is the chemical name for methadone hydrochloride. Methadone hydrochloride is a crystalline powder that is white, odorless, and has a bitter taste. It’s highly soluble in water, isopropanol, and chloroform, but practically insoluble in ether and glycerine. The racemic combination of methadone hydrochloride oral concentrate contains it. Methadone hydrochloride has a melting point of 235°C, a pKa of 8.25 in water at 20°C, a pH range of 4.5 to 6.5 in solution (1 part per 100), and a partition coefficient of 117 in octanol/water at pH 7.4.

Action Mechanisms
Methadone hydrochloride is a mu-agonist, a synthetic opioid analgesic with numerous qualitatively similar activities to morphine, the most notable of which affects the central nervous system and smooth muscle organs. Methadone is primarily used for analgesia, detoxification, and maintenance treatment in opiate addiction. Methadone abstinence syndrome is qualitatively comparable to morphine abstinence syndrome, although the onset is slower, the duration is longer, and the symptoms are milder.

The Central Nervous System’s Effects
Methadone causes respiratory depression by acting directly on the respiratory centers in the brain stem. Respiratory depression occurs when the brain stem respiratory centers become less responsive to both increased carbon dioxide tension and electrical stimulation.

Even in complete darkness, methadone produces miosis. Although pinpoint pupils are a symptom of opioid overdose, they are not diagnostic (e.g., pontine lesions of hemorrhagic or ischemic origins may produce similar findings). In overdose conditions, hypoxia may cause marked mydriasis rather than miosis.

In animals, some NMDA receptor antagonists have been demonstrated to cause neurotoxicity.
Gastrointestinal Tract and Other Smooth Muscle Effects
Methadone induces a decrease in motility in the antrum of the stomach and the duodenum, as well as an increase in smooth muscle tone. Food digestion is delayed in the small intestine, and propulsive contractions are reduced. Constipation is caused by a decrease in propulsive peristaltic waves in the colon, as well as an increase in tone to the point of spasm. Reduced biliary and pancreatic secretions, spasm of the sphincter of Oddi, and transitory increases in serum amylase are all possible opioid-induced consequences.
In animals, some NMDA receptor antagonists have been demonstrated to cause neurotoxicity.



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