Category: lorazepam (Ativan)

lorazepam (Ativan)

lorazepam (Ativan)

The drug lorazepam, also known by the commercial name Ativan, belongs to the benzodiazepine class. [3] It is employed in the treatment of anxiety disorders, insomnia issues, extreme agitation, active seizures, including status epilepticus, alcohol withdrawal, and nausea and vomiting brought on by chemotherapy. [3] It is also used to sedate patients who are receiving mechanical ventilation after surgery and to prevent memory formation. [3] [7] Along with other treatments, it is also applied to acute coronary syndrome brought on by cocaine usage. [3] It can be administered orally or as an injection into a vein or muscle. [3] When administered by injection, the effects start between one and thirty minutes after administration and can last for up to a day. [3]

Common Side Effects

Weakness, tiredness, low blood pressure, and a reduced effort to breathe are typical adverse effects. [3] When administered intravenously, the patient needs to be closely watched. [3] Suicidal thoughts may be more likely among sad people. [3] [8] With prolonged use, more doses might be necessary to achieve the same result. [3] Both psychological and physical reliance are possible. [3] If benzodiazepines are abruptly withdrawn after prolonged use, withdrawal symptoms may develop. [3] Negative consequences are more frequently in older adults. [9] Lorazepam is linked to falls and hip fractures in this age range. [10] Because of these issues, lorazepam use is often limited to two to four weeks. [11]

Drug Origin

The first patent for lorazepam was issued in 1963, and sales of the drug began in the US in 1977. It is listed as one of the essential medications by the World Health Organization [12, 13]. [14] It is accessible as a generic drug. [3] With more than 10 million prescriptions written in 2019, it was the 69th most often prescribed drug in the US.

Used for Anxiety
The short-term treatment of severe anxiety is done with lorazepam. The FDA in the US warns against using benzodiazepines like lorazepam for more than four weeks at a time. [11] [17] It is effective in treating panic attacks that come on quickly. [18]

The length of effects from a single dose of lorazepam make it a suitable option for the short-term treatment of insomnia, especially when there is a history of severe anxiety or night terrors. Lorazepam can successfully reduce agitation and promote sleep. Its action lasts only a little time. [19]

After using lorazepam for seven days, withdrawal symptoms such as rebound sleeplessness and rebound anxiety may appear.

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